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C6 GENETIC COUNSELLING: THE PSYCHOSOCIAL IMPACT IN BREAST AND OVARIAN CANCER FAMILIAL RISK A. Caruso1, F.M. Sega2, G. Maggi1, C. Vigna1, I. Palmieri3, R. Palmirotta4, A. Savarese3, F. Cognetti3 1 Service of Oncological Psychology, 2Dept of Surgery, 3Dept. of Medical Oncology, 4 Lab. of Clinical Pathology Regina Elena Cancer Institute, Rome, Italy Aim: to evaluate psychosocial variables of individuals who approach genetic counselling in order to: modulate the intervention of the team on needs of patients, survey psychosocial impact of genetic counselling's process and surveillance program, survey correlations between psychosocial variables and development of disease. Methods: 105 subjects who approach genetic counselling were recruited from April 2002 to January 2005. Psychological assessment was performed at: collection of family history and eligibility communication T0 blood-withdrawal T1 communication test outcome and proposal surveillance program T2 ; . Instruments: Minnesota Multiphasic Personality Inventory MMPI 2 ; for the assessment of personality; Family Adaptation and Choesion Evaluation Scales FACES III ; for family functioning and structure; Hospital Anxiety and Depression Scales HADs ; for assessment of anxiety and depression. Psychological assessment follows the steps of surveillance programs. Rating of MMPI only T0 and after annually. Results: 65 105 subjects recruited at T0 experienced BC or OC and 40 105 healthy women were members of high-risk families. The median age was 52 yrs range: 25 82 ; . subjects accepted to performe T1 psychosocial evaluation. In comparison with general population, significant higher levels raw score ; in hypochondriasis 12.4 ; , depression 24.8 ; , hysteria 26 ; , and psycasthenia 16.9 ; were observed at MMPI. At FACES III cohesion emotional tie between the relatives ; is higher than adaptation ability to cope with events ; being respectively 40.5 vs 31.7, and is not affected by counselling process. At HAD's adaptation disturbance for anxiety diminishes from T0 to T1 29% vs 14% ; while adaptation disturbance for depression increases 12% vs 20% ; . Conclusion: Preliminary data seem to confirm the crucial role of psychosocial evaluation in genetic counselling. This process in fact might have some impact on emotional wellbeing of high-risk population It is in progress a validation of a test for appraisal of the perception of genetic risk and the risk to develop cancer. Partially supported by Progetto Finalizzato Ministero della Salute, Italy, and Lega Italiana Tumori.
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A058 How To Break Bad News An Interactive Workshop S Dunn 1 ; * , F Boyle 1 ; * , P Heinrich 1 ; , P McLean 1 ; , M Hertzberg 2 ; 1. Cancer Communications Centre, University of Sydney, Sydney, NSW 2. SAC in Haematology Recent research has demonstrated that communication skills of clinicians involved in cancer treatment can be enhanced by training that involves opportunities to interact with simulated patients in a workshop format. Patient outcomes are enhanced when their concerns about diagnosis, treatment, prognosis and potentially threatening procedures are addressed, and realistic hope is maintained. This workshop will feature a simulated patient with newly diagnosed Diffuse Large Cell Non-Hodgkins Lymphoma, and will focus on a consultation in which prognosis and treatment are discussed. Facilitators with psychological and oncological backgrounds will draw on the evidence base underlying performance of this difficult communication task, in guiding participants to explore new strategies. A064 New Perspectives in Disorders of Iron Metabolism J Gollan Department of Medicine, University of Nebraska Medical Center, Omaha, USA Disorders of iron overload and deficiency are prevalent worldwide. Genetic haemochromatosis GH ; is the most common genetic disorder occurring in persons of northern European descent. The disease is characterized by defective regulation of intestinal iron absorption and progressive tissue iron accumulation. Despite the discovery that the HFE gene is defective in the and levocetirizine.
Leppert, P. S.; Fix, J. A. Use of everted intestinal rings for in vitro examination of oral absorption potential. J. Pharm. Sci. 1994, 83, 976. Tukker, J. J. In Vitro Methods for the Assessment of Permeability. In Oral Drug Absorption; Dressman, J. B., Lennernas, H., Eds.; Marcel Dekker: New York, 2000; p 51. 8. Irvine, J. D.; Takahashi, L.; Lockhart, K.; Cheong, J.; Tolan, J. W.; Selick, H. E.; Grove, J. R. MDCK Cells: A tool for membrane permeability screening. J. Pharm. Sci. 1999, 88, 28. Bancroft, J. D.; Cook, H. C. Manual of Histological Techniques; Chruchill Livingstone: New York, 1988; p 243. 10. Ingels, F.; Deferme, S.; Destexhe, E.; Oth, M.; Van den Mooter, G.; Augustijns, P. Simulated intestinal fluid as transport medium in the Caco-2 cell culture model. Int. J. Pharm. 2002, 232, 183. Timmins, P.; Dennis, A. B.; Vyas, K. A. Biphasic controlled release delivery system for high solubility pharmaceuticals and method. U.S. Patent 6, 475, 521, November 5, 2002. Emoticon: message #: 751 6 in response to 751 5 from: boogiwoman to: mrsjess88 date: sep-8 replies: 7 i had to take indocin after terb and mag didn't work and lopid!
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FC3.26.07 THE EFFECT OF INTRACELULLAR Mg2 + IN PRE-ECLAMPSIA Ana Mitrovic, Milan Djukic, Snezana Rakic, Nikola Antic Clinic of Gy and OBS Narodni Front, Medical Faculty, University of Belgrade, Yugoslavia Approximately 2-10 % of pregnancies are complicated by preeclampsia.The pathophysiology of preeclampsia is general arteriolar constriction and increased vascular sensitivity to pressor peptides and amines. The etiology of preeclamsia is unknown. We examined 105 gravids ; prospectively the corelation between intra and extracelullar magnesium deficit and Uterine artery Doppler in women with preeclampsia. We used bilateral early diastolic notch at 24 weeks as the definition of an abnormal waveform circulatory parametars-Pi, Ri, of gravids art.utrina were excluded ; . For evaluation of RBC and plasma magnesium and calcium level we used AAS-atomic apsorption spectrophotometry. According to our results, in majority of cases, we determinated significatly low level of intracellular magnesium 0, 86 + 0, 22 mmol l in group with bilateral notch, and positive corelation between bilateral notch, intracelular magnesium deficiency, increase level of intracelullar calcium 0, 63 + 0, 18 mmol l ; and preeclampsia. These results support hypothesis that disbalance of intracelullar electrolites, expecially intracelullar magnesium and calcium are strong determinants of risk of preeclampsia because these facts could cause grater excitability of vascular smooth muscle contraction.
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Received 27 July 2004. Accepted 15 June 2005. Published on the NRC Research Press Web site at : apnm.nrc on 3 March 2006. F. Ftaiti.1 Institut Suprieur du Sport et de l'Education Physique, Sfax, Tunisie; and Department of Physiology and Functional Explorations, Faculty of Medicine, Ibn el Jazzar, 4000 Sousse, Tunisia. M.P. Dantin, C. Nicol, and L. Grlot. Unit Propre de Recherche de l'Enseignment Suprieur EA 3285, Department of Biology of Physical Activity, University of the Mediterranean, Marseille, France. C. Brunet. Service of Sports Medicine, Parc Salvator, Marseille, France.
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705 - Anesthesiology: today and tomorrow, edited by TH Stanley, WC Petty Mezon ; , 564 - Basics of anesthesia, by RK Stoelting, RD Miller Maltby ; , 309 - Les Benzodiazepines en anesthesie-reanimation, C Conseiller et al. Crama ; , 565 - Cathetirisme veineux central percutane", M Rosen, IP Latto, WS Ng, traduit de l'anglaise par F et RH Polge Sahab ; , 96 - Clinical anesthesiology, by BR Brown Jr., CD Blitt, RW Vaughan Mezon ; , 311 - Critical care of the child, ed. by O Prakah Edmonds ; , 451 - Current concepts in regional anaesthesia, edited by JW Van Kleef, AGL Brun, JS Spierdijk Kozody ; , 96 - Handbook of regional anesthesia, edited by PP Raj Poon ; , 679 - How to edit a scientific journal, Claude T Bishop Craig ; , 449 - MCQ Tutor anaesthesia, 2nd ed, AW Grogono, TH Howells, JL Seltzer, S Mann Mclntyre ; , 451 - Manual of cardiac anesthesia, edited by SJ Thomas Whalley ; , 195 - Manual of obstetric anesthesia, edited by GW Ostheimer Palahniuk ; , 195 - Manual ofpediatric anaesthesia, 2nd ed. edited by DJ Steward Duncan ; , 309 - Opiodis in anaesthesia, edited by FG Estanfanous Davies ; , 449 - Pain, edited by R Rizzi, M Visentin Catchlove ; , 312 - Lapathologie respiratoire in anesthesie-reanimation, by CHU Pitie Wahba ; , 566 - Physiology for the anesthesiologist, 2nd ed. N Goudsouzian, A Karamanian Imrie ; , 196 - Pulmonary physiology in clinical medicine, 2nd ed. by GM Tisi Knill ; , 196 - Quality of care in anaesthesia practice, edited by JN Lunn Pope ; , 311 - Respiratory physiology, 3rd ed. by JB West Kolton ; , 679 - Recent advances in anaesthesia and analgesia. Vol. 15, ed. by RS Atkinson and AP Adams Enright ; , 450 - Textbook on pain, edited by PD Wall, R. Melzack Kozody ; . - Trauma and the anaesthetist, JC Stoddart Bristow ; , 450 Brachial plexus block, see Anaesthetic Techniques, Regional.
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